I think it would depend on what you wanted to end up with. A monochromatic quilt would require a variation of the same color. If you wanted two or three colors in it, then divide up the fat quarters into two or three color variations. If you were looking for drama, I'd go with a black and red, or a black and white. If you are interested in a scrappy quilt, you could use scraps, or many different colors and prints in your fat quarters. What a lovely quilt! Good luck to you!