There's a great class on Craftsy on "Quilting a Large Quilt on a Domestic Machine." It really helped me. Now what I do is divide a big quilt into 4 pieces, quilt each of the 4 sections, which is much easier since it's so much smaller. Then I put the 4 pieces together. This is only one of her suggestions, and the one I find easiest. There are several more demonstrations and tutorials on doing it different ways, including quilting the whole thing. It's really worth your while if you want to do large quilts at home.