I finished hand quilting a quilt in the front passanger seat of a motor home. any farther back, and it's too bouncy. even took my sewing maching with me one winter, but never could get the hang of it. never enough room, or a comfortable enough table. did take a 'big' quilting frame 'loaded' once. quilted on a dear jane quilt some. but still, took up tooo much room to set it up. and couldn't get comfortable.
now if you were 95 lbs, and your motor home was a 70 footer, with 4 expando's I see where it would be possible.