Downstairs (an entire, but smallish room) is my fabric storage, cutting table and all cutting needs, L-shaped corner tables w/machine for quilting, lightbox, marking utensils, extra machines, patterns & books, design wall, and other quilt-y odds & ends. Upstairs (sharing with bedroom furniture) is the machine I use to piece and for machine embroidery, adjacent to my computer where all ME designs are stored, my ironing board, most of my thread of all types, iron/steamer, and a shelf unit with more odds & ends. I've had this set-up for many years and I like it very well. The trips up and down the stairs do not bother me and generally are not so frequent as to be exhausting. I often carry assembled, pinned but not sewn, blocks upstairs on felt covered stryrofoam boards. The quilt I'm assembling now is all cut, so all the pieces have travelled upstairs together in a pizza box.