What I've been doing lately on the back of my quilts is putting a panel about 3' x 4' (varies by quilt) in the center and then adding the sides and top and bottom.
It all started when I was doing panel quilts. I take the 3 x 4 panel, batting and backing and quilt it like a small quilt,
square it up and add front and back to one side, spray baste the batting in
and quilt that side, then I do the other side, then top and bottom.
I don't have the room to quilt a large quilt so this works great for me.
What ever part I'm quilting is always on my left so I don't have it rolled up under the machine.
I am doing this now on a full quilt, so far so good.