I'm not sure about now, but in the past, thread definitely had a nap, so it should be sewn as it comes off the spool (knot end toward spool).
Some manufacturers may have altered their process so the practice no longer applies. I'd still do it if I were you, just in case you happen to be sewing with a manufacturer's line that hasn't implemented the process yet...or in case you happen to be using an old spool of thread.
I hand-sew bindings with the same thread I piece with -- cotton covered polyester.
Last edited by TeresaA; 03-15-2014 at 08:23 AM.