If I go a long time without quilting, it will take me awhile to redevelop my "eye" for 1/4 inch seams, so my seams will be off sometimes. Ooops, sometimes my corners don't join perfectly. Shrug. It's supposed to be FUN!
If perfection is your goal, take your big machine. If your goal is to enjoy your hobby with the least amount of struggle and concern, then find a good way to get as close as you can and take the machine that is most comfortable to bring.
I stopped quilting for 10 years because the hobby was becoming too much of a burden. Don't let that happen to you. On the bright side, when I came back, I barely remembered some of my projects, and they felt like they were done by someone else. I was a whole lot kinder to them and actually have pieced some of the blocks together that I had abandoned before! It's great.
It's one of those life is too short situations, as far as I'm concerned ;-). Do what makes you the most comfortable.