My sewing room is upstairs. I actually share the space with my husband. His half of the room is filled with his gun collection, horn mounts, and fly tying bench. Talk about the Odd Couple. I refer to it as the "Horny Sewing Room". The advantages (?) are, I tend to get more legitimate exercise going up and down the stairs and I too have lousy knees. Another advantage of having the room upstairs is I can abandon a project for a couple of weeks and no one is the wiser. Don't have to make the room tidy or presentable until I'm darned good and ready. Also, it gives me a one floor cushion of space, when husband and I need a little time apart with both of us being retired for two years now. It helped keep our 39 year old marriage rock solid after an extremely long winter chocked full of Cabin Fever.