My Dad was a contractor and always said--not too spread out of kitchen(called them "cook killers" if they involved lots of steps between appliances) and main bedroom, bath, living and LAUNDRY on the main floor. I took his advice when we built out house--if I had do-overs, I'd add a large room for my sewing and long arm! Sewing is in one of the kids old bedroom upstairs and long arm in basement walk-out. The saving grade with it is that is a walk out basement, so on days when my knees just don't want to manage the stairs (and that has just been in the last 8 years--it happens no matter how good of shape you might be in) I walk outside and around--not fun in winter. So a definite vote for main floor--especially with moving that long arm in!