What a great idea. A book instead of a quilt, if I understand you correctly.
I would suggest you use the same steps as for a signature quilt. Use all cotton prewashed and untreated fabric. No starch or sizing or softener or scent. Make file folder templates the same size as the material pieces you choose and so that the front is cut out where you want the signatures to be and you have ample seam allowances. I prefer to mark a baseline on the inside back cover of the file folder for the ease of those signing. Have plenty of file folder templates, pigma pens, and someone assigned [preferably more than one person] to supervise the process as the pens will "walk away."
Once you have all the signatures heat set them. Then you are ready to put it all together. You may or may not want to use interfacing to make the pages firmer. Your choice there.