I have arthritis and fibromyalgia in my hands. I machine sew my bindings on. Sew the binding to the back of the quilt and bring it around to the front. You can use a decorative stitch to sew it down, a blanket stitch, zig zag... It is also an opportunity to use varigated threads, you can match the thread to the binding,use invisible, or zing it up with a contrasting color.
Some sew the binding to the front, wrap to the back and pin, glue baste, etc... Then you stitch in the ditch on the front side by machine. I struggle with this method, as it is hard to see what is going on in the back...if the binding is laying straight and even, unless I glue baste it down first.
There may be a few hand stitches needed in the seams of the mitered corners.