I have a Cameo, plus the "little sister" Portrait. I've only ever used it for scrapbooking, so I can't speak on how it does with cutting fabric. However, one of the things I LOVE about the machine and the software is the ability to use any graphic and/or font that is on your computer and convert them to cutting files. Plus, the store is PACKED full of great designs!
I agree with Cheshirechat.... For mass-production of quilt pieces, the AccuQuilt or Sizzix machines are going to suit your needs better.