I would do it if I had a table that needed covered that I used all the time. I made a large bed runner size mat for my kitchen island for putting pizzas and hot pans on and it gets spilled on all the time. I also have scrappy placemats that have withstood all sorts of things. I just use stain remover on them and wash them. So far, nothing has stayed on them. The only thing I think of when I think of a quilt for the entire table is drink cups might spill easier.