I also have the 350e and love it! I've had it for about five years and really enjoy using it. Mine came with a nice CD of designs besides the built-in designs, and I've also downloaded a number of free designs from the Janome site and others that have come in handy. Just pop them on the included USB drive and plug it in to the machine. My friend bought one a year ago and we were just chatting about how many gifts she's made with it in the past year. She monograms everything!
I also did not want a combo machine because some designs do take quite a while to stitch out. I guess it would depend on how often you sew and if this would be your only sewing machine.
Whatever you get, enjoy it!