In case you can't find the answer, here's what that FAQ page says:
This error 42 is Vista’s way of asking you for more permission. Here’s what to do:
The short way:
* Hold down your keyboard SHIFT key and Right-click the EQ6 shortcut on your desktop.
* Choose Run As, or Run..., or Run As Administrator from the menu.
* Allow this, then continue on with the activation.
The long way:
* Click START > Computer.
* Double-click on your local disk C drive.
* Double-click these folders: Program Files > Electric Quilt Company > EQ6.
* In the opened EQ6 folder you will see two red and white files.
* Right-click on the red and white EQ6 file that is an application file.
* Choose Run as administrator.
* Choose to Allow this and then continue with the activation.
http://www.electricquilt.com/Support...te.asp#vista42
http://doyoueq.com/phpBB3/index.php