Depends on what color of the quilt it is. If I'm not sure of a spot, I use a little Dawn in water. Then use a Q-tip dipped in the water or you could try straight Dawn on a q-tip. I would use it in an inconspicuous spot. Don't need a lot just a little and see what happens. If you can use it in a light area of the quilt try that. if it comes out then You may be able to just hand wash. Let dry on a towel. hope works for you.