I felt just the opposite. Fell in love with the Sweet Sixteen and after a 3 hour lesson on a standup I hated moving the handles. It was just so mechanical, not textile handling. Standing up all that time just killed my knees. Also, I had no where to put a monster frame, and finally, the cost of standups is WAY more than that of the sitdowns. All the ones I've seen cost as much as a good car. And I never baste when I quilt on my Sweetie. Sometimes I spray baste, but mostly I just spread the layers out, smoothing both sides and put in a few pins in the center and at the corners. You just roll the edges in on a large quilt, work in a puddle, and smooth it out as you go.
Most important is to do what your gut, heart, feelings tell you. Maybe take a class first, and see how you like standing up for hours at a time, to be sure, but everyone is different.