I've used many wool battings-hands down my favorite... I use either Dream Wool or Hobbs Wool... I have given two quilts with wool battings to family members who swear they are Horribly allergic to wool... Neither of them have had any problems with their quilts. I let them know I would make them new ones if a problem came up... One of them has had their quilt for about 5 years...and she uses it all the time. I don't know if the wool battings are somehow (hypoallergenic).. But I have not found any problems using them