Thanks everyone! I was mainly concerned the awkward seams would cause odd bulking or something but it doesn't sound like that will be the case.
I initially was pressing my seams open (only had done a few) but had read that this could possibly lead to "bearding" - since I do plan to use this quilt I decided to press them to the sides instead. But boy they sure do lay flat with the open seams! When I get to making more decorative quilts I'm sure I'll use that technique at some point.