I have a beautiful quilt my mother made using a combination of cotton and polyester. She liked the poly because it did not wrinkle. Mom machine stitched and hand quilted all of her quilts. The problem I find is that poly requires a lower heat for pressing. I also have trouble keeping seams accurate as the poly slides. That said, I use it church mission quilts which are made up of squares and tied. I have found some great fabric for mission quilts on my guild's free table.