I use Ecos - it's non-allergenic and approved by PETA. I never sort clothes. The only thing that gets washed separately is a pair of new jeans. After about 10 washes, they are good to go. We wash in cold water. I've made a lot of the shirts, sweatshirts and household items like shower curtains etc. If it can't go in the wash, I don't want it. Quilt goes in by itself just for room in the washer. I had more trouble from a washer that was leaking grease than color transfer.