I love hand quilting and have done a few. Do you have a quilting frame or will you be quilting in a hoop? If this is your first hand quilting, I would suggest that you take a few scraps of batting that you have around and make a sample sandwich for practice. I've used warm and natural but I'm not fond of it for hand quilting. It is great for machine quilting. My reasons are that it is dense and in my opinion, harder to get small stitches. The thinner the batting, the smaller stitches I am able to make. I used a cotton/poly blend on the last quilt I did by hand and the stitches turned out so nice. I don't remember the brand. I got it at my LQS and it was for summer weight quilts. I've never worked on wool so I can't give any ideas on that. Good luck. Let us know how it goes for you.