I make them all the time. When you are making a baby quilt you have to take into account the parents. Many now a days will not use anything unless it is 100% organic whatever. And if they get a home made gift and they don't know if it is 100% cotton they won't uses it and many times will just get rid of it. I knew two moms who actually did this. I had made them a quilt and knowing their desire for organic and cotton went with that. I have also used bamboo "pollyfill"(stuff you shove in a pillow or stuffed animal) on a baby quilt and while the quilting was a pain and messy it was the lightest softest one ever. I have never used wool but have heard real good things about it. I would use just what you like with the parents in mind.