I made a wonderful quilt for one of my sister in laws with dupioni silks a few years ago, dupioni really isn't too difficult to work with and quilts beautifully. You need a good, lightweight fusible interfacing and a New Sharp blade in your rotary cutter. I good, new, sharp needle in your machine and fine,sharp silk pins. Fuse the interfacing to the silks before cutting and seriously the new sharp blade is probably the most important thing.