you sure can. I was making a cover for my heating pad (all on the serger) this weekend and wanted to quilt part of it. I took two long pieces side by side and then since I was doing decorative stitching that would require stabilizer I placed the batting on top of that and serged (using cover stitch) them together. You can do the same with a zig zag stitch. It turned out great and now my heating pad that litterly stays out on the sofa constantly matches my throw cushions. It looks so much nicer than that blue thin bag that they are covered with. Now I'm making a zebra print one for my daughter, who is only 25 but her heating pad stays out constantly too. If you got to use it might as well make it look good