There are many videos out in cyberspace on appliqueing quilts. I'm sure you will find one to help you. I would think that if you had the applique secured well so it wouldn't move you should be able to do what you want. As long a you don't have a lot of small areas like skinny stems or such, shouldn't be too hard. If it doesn't work out you can start over.Many use a fusible adhesive to help secure.