I've mixed hand and machine quilting before. I did stitch-in-the-ditch on all the blocks by machine and then hand stitched a design inside each block. It looks just fine.
If half the quilt is machine quilted and the other half is hand quilted... I think that would look too obvious for me. But if the goal is to get it finished.... so be it.
Whatever you choose only matters to you if it's your quilt.