I bought fleece from Joanns after sme careful comparison shopping as they have many kinds: not too thick; not too slippery like Minky or that dimpled stuff that loses its shape; I checked to make sure it wouldn't shed by rubbing it against some plain cotton fabric; I checked the amount of stretch and whether it seemed to go back in shape right after I stretched it out.
I did spray baste (heh heh guilty as charged!!!), but I noticed the back of the fleece didn't stik as nicely as I would have liked to the batting. I did a good amount of structural quilting before I did any decorative stuff, and I kept the decorative stuff to a minimum, like sun motifs in setting triangles, or nice curlicues going up a path of HST or big meanders or whatever. I'm no quilting genius so no fancy loops and feathers.
I kept quilting stitches a little bigger than usual and kept an eye out for any pulling during the quilting because you might end up with a little pinch of fabric inside one stitch due to the bulk of the fuzz underneath.
Good luck, have fun with it!