Whatever you do, don't overfill the puffs! Underfill is fine; overfill is not. I made that mistake with my first-and-last puff quilt. Overfilling makes it very difficult to sew the puffs together. When finally finished, the whole thing was so stiff its only possible use was as a pet bed.
The nicest puff quilt I ever saw was made from silk by hand (by a boy who needed a long bed rest while recovering from TB, I think).