I can see where one might have to use more spray to baste poly batting, but Thermore poly is much denser -- not thicker, just more densely made - than regular fluffy polyester batting. I've never tried it but can't imagine why it would be all that much more trouble.
Are you making a quilt with Thermore? I know it's widely used in wall hangings and the quilted clothing, but for the thinnest bed batting, I'd recommend Quilters Dream Request loft batting.
Jan in VA