The weights won't cause any differences unless you are hand quilting. I've made a couple of couch quilts using a combo of these fabrics and had no problems. I found it easier for me to use different needles when hand quilting the homespun than when hand quilting the cotton. I can't remember what I used, but I seem to think it was a longer needle that worked better than a between. I hand quilt without a hoop - perhaps that made the difference.