I'm of the camp of packing up as much as possible but also make up a couple of 'kits' for yourself along the way. Both machine and hand work. Keep your machine out. In the packing process, if you can, figure out which items you're going to have in your respective north and south homes and label appropriately. Even if you're going to move your fabric within your current house, possibly sort those internal destinations to their ultimate north or south locations. Will make your end packing easier. And I agree with keeping a box in each room for the 'last used/first opened' things.
Good luck with selling your home and upcoming retirement.