I have made quilts - years ago from polyester blend fabric, used for clothing back in the day. It does not fade like cotton and wears like iron. Back then I only hand quilted and had very good luck with it. I have bunches and gobs of it and if I live long enough I plan to make more and I will machine quilt them. I am not talking about poly knit fabric, just dress weight.
I mostly use polyester batting and like it better than W&N. Warmth without the weight.