A & E Pharmacy in Pensacola is one not to be missed! It doesn't look like much from the outside but is wonderful inside. If by chance you are here in your birthday month, sign up for their Club Membership. It's $20 but you get 50% off on a 3 yard cut of fabric your birthday month. It includes backs, so for $20 you can pay $20 to save $40 on a backing fabric, making it a $20 discount. There is also a very nice one in Gautier, MS. The name eludes me but it just south of I-10. And there is Quilting by the Bay in Panama City. But that is further than 2 hours from you. Those are the best in the area. (In my opinion) There are a few sewing machine centers that sell fabric also, but I think these 3 are the best on the Coast. I haven't head of one in Destin. Doesn't mean it's not there.