Each time I have tried hand quilting, I have bought a different brand of thread. I'm really liking the Treasure thread from Superior threads the best. It is glazed, and it hasn't gotten knots in the middle of sewing like the ones I've tried in the past. Some of the threads I've used in the past were the right weight, but didn't have the glaze. For me, that makes a difference. Even with the thread conditioners or beeswax, I would still get knots.