I usually start with a fabric I like and pick others to complement it. Sometimes, DH and I have color disagreements so I out it all down, let it percolate or ferment, and then come back. Usually I go with a combination of both of ours. The one I know I might struggle with is the one I'm planning for my mom. Found out what colors she doesn't like and am going from there but at least I have a pattern picked out. Hers will be florals with some other things thrown into the mix. Am hoping it'll be less chaotic than it currently sounds. The back will be another quilt but with all cat fabrics.