I am definitely a leftie! I love my left handed scissors but have no problems with quilting and none of my left handed friends do either. We are in a group that quilts together once a week and we are about 50/50 (left vs right handed). I have quilted for at least 15 years and was not aware there was a difference in rotary cutters. I have lately found that titanium blades last longer but other than that Olfa has worked well for me!