I don't know that I would spray baste for hand quilting. It may be too much resistance and gum up your needle too much. Beyond that, I hand quilt with W&N all the time. It's all I've ever used. I have an entire bolt of the stuff so it will be quite a while before I try my hand at something different. My friend uses Quilters Dream 100% cotton batting. It does have a very nice drape to it and that is what I'll be trying if I ever run out of the W&N.