So far, I've only hand quilted with Quilter's Dream wool and Warm and Natural. I find the W&N difficult to hand quilt in comparison to the wool. I think the wool is a fussier batting, though, at least, the Quilter's Dream wool. It can't be exposed to heat because it's thermally bonded. I don't think you could go wrong with the Hobbs or Quilter's Dream low loft cottons. That will be my next kind of batting to try.