It's pretty much all I use. I piece and machine quilt (sit down HQ) and have had no issues with it. I also hand piece (EPP) with it and have never had any problems. Just make sure your sewing needle matches to the 50wt. I don't know enough to tell you how they calculate the weight, but can definitely say 50wt is just fine!
I do like thinner/silk for hand applique though!