While I realize hand quilting is what your grandma was doing, women also machine pieced at that time (my grandma's quilts were usually a mix) so you can use your machine if hand quilting isn't a skill you have. I have a top from my grandma to finish for the grands and great grands. If I had to hand quilt them, they would never get done! You might want to consider a 9 block wall hanging with the center block being a picture of your Grandma and a short paragraph about her printed on muslin. Depending on how many you'd need to make either all the blocks but the center could be hers or the 4 corner blocks could be hers and the top, bottom and side center blocks could be solids picking coordinating colors from the prints she used or muslin. If muslin, I'd put sashing around the muslin blocks to add definition & interest.