Can you find out how they are decorating the nursery? I would go with whatever their plan is, I'm sure they have one. My daughter and her husband did not want to know the gender of their three kids and picked such a cute nursery theme. They used it for the first two, a boy and then a girl. Dad even painted a mural on the wall. It was Carter's John Lennon line called Imagine. So cute. I wasn't quilting at the time, so didn't add to the theme that way. For the third one, a little girl, they were in a new house and didn't really worry about a theme. I did make a quilt for her but waited until I knew who she was
Since then I also made a quilt for her big girl bed. Such fun.