I machine quilted a king size quilt, 110" x 110", on my Sears Kenmore several years ago, and many queen and a king size quilt on my Singer (burned out my Kenmore-not happy when I saw smoke coming out of my sewing machine), then my Janome 4000, and I have had good luck, although I didn't do anything fancy, mainly straight line stitching and SID. I even did a full size quilt for our DGD with many, many appliqued flowers, pinwheels, as well as the pinwheel blocks, etc. My DS, DDIL and DGD were really happy with it, so all the times I grumbled (certainly that wasn't me, maybe that was my alter quilter) were worth it when my DGD, jumped up to give me a big hug and kiss, telling me she loved it very, very much. I had pieced the quilt right before having a torn rotator cuff replaced, and quilted it afterwards, just in time for Christmas. So I say yes, you can quilt a queen size quilt on your machine. I generally start in the center, work my way out to the borders, then turn the quilt around and do it again. Just take your time and I'm sure you will do fine. By the way, I used W&N batting, which I think helped. Just FYI, I attended a lecture at my local guild from a quilt teacher who said that she starts on the outside and worked her way in. She said that if your quilt is properly basted, you should be able to start anywhere to machine quilt. Take your time, enjoy the process and I'm sure you'll do fine.