I'm a trial-and-error person too. That's why I call my room 'the quilting lab'!
I also think it depends on who's the responder to the question I'm asking. Bearisgrey, I generally heed well your expert advice on this Board, but one place we diverge is pre-washing. Did it once, horrified by the result, killed myself getting the fabric ready to cut, just can't face doing it again!