I have made about 15 mondo bags. (Too many to keep track of) I have arranged the squares in many ways. "Scrappy", with several different fabrics is the easiest, as you just lay them out and do not worry, having five or so fabrics you will get a design, when you are finished. The last bag I made I did a scrappy black and white but every other square was the same purple fabric. The bottom corner had to have the same color, I placed a purple square, for it to come out not touching when you sewed the four panels together. I agree, it does not matter, if two like squares are touching most of the time. My advice to you would be to make it scrappy the first couple of times until you get the idea of it, and then get picky about having a pattern. The bigger challenge for me is always on how to place a pocket inside. I have done it, but I usually choose to just leave the pocket out.