What a treasure you have! I'd love to have found something like this that my grandmother did. Well..here is what I would do with it. I would NOT take anything apart, instead I would ADD to the smaller blocks to make them a size that would work with the larger blocks. Keep in mind that not all the rows or even all of the columns HAVE to be the same sizes. Sometimes it is nice to vary the size of them anyway..it adds interest in my opinion. When you have the blocks in sizes that you want to work with, lay them out and you can even add sashing to the blocks to make them all play together nicely. Sew them together and violla...a quilt done!
Good luck..keep us posted...we can add further input if it were possible for you to post some pics of these treasures..hint..hint..