I only started FMQ on my DSM earlier this year, but have quilted 4 queen sized (100"x100") quilts and they took 25 or so hours to quilt. I used about 3000 yds of thread, so the quilting was pretty dense. I used my new Juki TL2010Q and found it pretty easy to move the quilt around under the harp. I found (after the first quilt) that only pinning the center of the quilt sandwich until that section was quilted made it much easier to keep any wrinkles from developing in the back, as I would loosely pin the next section I was going to quilt only after more central sections were done. This also made assembling the quilt take much less time--under an hour, which is much less than it took when I pinned the entire thing in one go (and had to move many pins as I got away from the center of the quilt).