It says used for quilting, so I'm sure you can the instructions say you can use something to stick it on the fabric such as glue stick or pens to place it on the quilt to keep it from moving I used clear tape. Just make sure when you put the design on let it dry before sewing threw it I let mine dry over night but a couple of hours should be alright too. Oh ya if you cats put it up high, my cat kept trying to smell of it and mess with it while it was on the kitchen table.