I have next to zero floor space and would have major knee/back issues if I ever tried it to begin with! I use my cutting table (one like they sell at JAF) to sandwich my quilts regardless of size of the quilt. Start in the middle of the quilt and use big binder clips to hold the layers in place as I'm working on them. I either pin or thread baste depending on size of the quilt (larger ones get thread basting as it reduces weight in my opinion). Once I get the center basted, I slide the whole thing left/right/up/down as needed to get the entire quilt basted. Can be a tedious process but I'm not crawling around on the floor or have other areas of the house tied up for long periods of time.