Oh! I'm drooling! Yes, wool is a great fabric to use for quilting. It's wonderful for applique because the edges don't fray & the color is so saturated it makes the quilts seem to glow. You would definitely want to wash them to make sure they shrink up, but I think that's about it.
My husband has a quilt made from polyester that his grandmother made him about 35 years ago. The darn thing is just as bright and useable as the day he received it.
If you decide to make a quilt for someone with Alzheimers, it is recommended to use various fabrics with different textures and feels to them. Your polyester fabrics would work great for this, as it would for quilts made for Rest Homes and Veteran's Homes, where such quilts get washed in heavy detergent quite often. Just a thought.